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feat(frontend): add v4 LoF curation section to Data page
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‎browser/src/DataPage/GnomadV4Downloads.tsx‎

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@@ -600,6 +600,52 @@ const GnomadV4Downloads = () => {
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</ListItem>
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</FileList>
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</DownloadsSection>
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<SectionTitle id="v4-secondary-analyses" theme={{ type: 'datasets' }}>
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Secondary Analyses
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</SectionTitle>
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<StyledParagraph>
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Additional research analyses created using the core gnomAD releases in collaboration with
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members of the gnomAD steering committee.
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</StyledParagraph>
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<DownloadsSection>
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<SectionTitle id="v4-lof-curation-results">Loss-of-function curation results</SectionTitle>
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<p>
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For information on v4 loss-of-function curation results, see{' '}
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{/* @ts-expect-error TS(2769) FIXME: No overload matches this call. */}
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<ExternalLink href="https://doi.org/10.1038/s41586-020-2308-7">
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<em>The mutational constraint spectrum quantified from variation in 141,456 humans.</em>{' '}
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Nature 581, 434–443 (2020)
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</ExternalLink>{' '}
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(all homozygous LoF curation results),{' '}
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{/* @ts-expect-error TS(2769) FIXME: No overload matches this call. */}
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<ExternalLink href="https://doi.org/10.1038/s41586-020-2329-2">
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<em>Transcript expression-aware annotation improves rare variant interpretation.</em>{' '}
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Nature 581, 452–458 (2020)
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</ExternalLink>{' '}
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(haploinsufficient genes LoF curation results), and{' '}
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{/* @ts-expect-error TS(2769) FIXME: No overload matches this call. */}
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<ExternalLink href="https://pubmed.ncbi.nlm.nih.gov/37633279/">
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<em>
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Advanced variant classification framework reduces the false positive rate of predicted
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loss-of-function variants in population sequencing data.
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</em>{' '}
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Am J Hum Genet 110, 1496-1508 (2023)
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</ExternalLink>
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.
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</p>
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<FileList>
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{/* @ts-expect-error TS(2745) FIXME: This JSX tag's 'children' prop expects type 'never... Remove this comment to see the full error message */}
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<ListItem>
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<DownloadLinks
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label="Incomplete penetrance LoF curation results"
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path="/release/4.1/lof_curation/incomplete_penetrance_curation_results.csv"
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/>
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</ListItem>
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</FileList>
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</DownloadsSection>
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</>
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)
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}

‎browser/src/DataPage/__snapshots__/DataPage.spec.tsx.snap‎

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@@ -7300,6 +7300,145 @@ exports[`Data Page has no unexpected changes 1`] = `
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</li>
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</ul>
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</section>
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<span
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className="c8"
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>
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<h2
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className="c9"
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>
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<a
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aria-hidden="true"
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className="c10 c11"
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href="#v4-secondary-analyses"
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id="v4-secondary-analyses"
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>
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<img
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alt=""
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aria-hidden="true"
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height={12}
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src="test-file-stub"
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width={12}
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/>
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</a>
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Secondary Analyses
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</h2>
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</span>
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<p
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className="c12"
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>
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Additional research analyses created using the core gnomAD releases in collaboration with members of the gnomAD steering committee.
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</p>
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<section
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className="c16"
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>
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<span
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className="c8"
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>
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<h2
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className="c17"
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>
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<a
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aria-hidden="true"
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className="c10 c11"
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href="#v4-lof-curation-results"
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id="v4-lof-curation-results"
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>
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<img
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alt=""
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aria-hidden="true"
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height={12}
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src="test-file-stub"
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width={12}
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/>
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</a>
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Loss-of-function curation results
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</h2>
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</span>
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<p>
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For information on v4 loss-of-function curation results, see
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<a
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className="c7"
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href="https://doi.org/10.1038/s41586-020-2308-7"
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rel="noopener noreferrer"
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target="_blank"
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>
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<em>
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The mutational constraint spectrum quantified from variation in 141,456 humans.
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</em>
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Nature 581, 434–443 (2020)
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</a>
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(all homozygous LoF curation results),
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<a
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className="c7"
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href="https://doi.org/10.1038/s41586-020-2329-2"
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rel="noopener noreferrer"
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target="_blank"
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>
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<em>
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Transcript expression-aware annotation improves rare variant interpretation.
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</em>
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Nature 581, 452–458 (2020)
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</a>
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(haploinsufficient genes LoF curation results), and
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<a
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className="c7"
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href="https://pubmed.ncbi.nlm.nih.gov/37633279/"
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rel="noopener noreferrer"
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target="_blank"
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>
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<em>
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Advanced variant classification framework reduces the false positive rate of predicted loss-of-function variants in population sequencing data.
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</em>
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Am J Hum Genet 110, 1496-1508 (2023)
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</a>
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.
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</p>
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<ul
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className="c20"
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>
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<li
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className="c21"
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>
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<span>
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Incomplete penetrance LoF curation results
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</span>
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<br />
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<span>
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Download from
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<a
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aria-label="Download Incomplete penetrance LoF curation results from Google"
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className="c7"
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href="https://storage.googleapis.com/gcp-public-data--gnomad/release/4.1/lof_curation/incomplete_penetrance_curation_results.csv"
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onClick={[Function]}
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rel="noopener noreferrer"
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target="_blank"
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>
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Google
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</a>
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/
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<a
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aria-label="Download Incomplete penetrance LoF curation results from Amazon"
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className="c7"
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href="https://gnomad-public-us-east-1.s3.amazonaws.com/release/4.1/lof_curation/incomplete_penetrance_curation_results.csv"
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onClick={[Function]}
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rel="noopener noreferrer"
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target="_blank"
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>
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Amazon
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</a>
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</span>
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</li>
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</ul>
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</section>
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<span
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className="c8"
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>

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