diff --git a/hibernate-core/src/main/java/org/hibernate/query/spi/AbstractCommonQueryContract.java b/hibernate-core/src/main/java/org/hibernate/query/spi/AbstractCommonQueryContract.java
index 499641be6512..fe40ab83a4b5 100644
--- a/hibernate-core/src/main/java/org/hibernate/query/spi/AbstractCommonQueryContract.java
+++ b/hibernate-core/src/main/java/org/hibernate/query/spi/AbstractCommonQueryContract.java
@@ -824,7 +824,7 @@ public CommonQueryContract setParameter(String name, Object value) {
 		final QueryParameter<Object> param = binding.getQueryParameter();
 		if ( param.allowsMultiValuedBinding() ) {
 			final BindableType<?> hibernateType = param.getHibernateType();
-			if ( hibernateType == null || isInstance( hibernateType, value ) ) {
+			if ( hibernateType == null || value == null || isInstance( hibernateType, value ) ) {
 				if ( value instanceof Collection && !isRegisteredAsBasicType( value.getClass() ) ) {
 					//noinspection rawtypes
 					return setParameterList( name, (Collection) value );
diff --git a/hibernate-core/src/test/java/org/hibernate/orm/test/query/hql/FunctionTests.java b/hibernate-core/src/test/java/org/hibernate/orm/test/query/hql/FunctionTests.java
index f8e3f9dfc75e..70dc3f410cff 100644
--- a/hibernate-core/src/test/java/org/hibernate/orm/test/query/hql/FunctionTests.java
+++ b/hibernate-core/src/test/java/org/hibernate/orm/test/query/hql/FunctionTests.java
@@ -2386,10 +2386,15 @@ public void testIn(SessionFactoryScope scope) {
 							session.createQuery("select 1 where 1 in :list", Integer.class)
 									.setParameterList("list",List.of())
 									.list().size() );
+					assertEquals( 0,
+							session.createQuery( "select e from EntityWithOneToOne e where e.other in (:list)" )
+									.setParameter( "list", null )
+									.list().size() );
 				}
 		);
 	}
 
+
 	@Test
 	public void testMaxGreatest(SessionFactoryScope scope) {
 		scope.inTransaction(