diff --git a/onnxruntime/python/onnxruntime_inference_collection.py b/onnxruntime/python/onnxruntime_inference_collection.py
index 4c3313046457c..91216473bcad2 100644
--- a/onnxruntime/python/onnxruntime_inference_collection.py
+++ b/onnxruntime/python/onnxruntime_inference_collection.py
@@ -397,6 +397,16 @@ def run_with_iobinding(self, iobinding, run_options=None):
         """
         self._sess.run_with_iobinding(iobinding._iobinding, run_options)
 
+    def set_ep_dynamic_options(self, options: dict[str, str]):
+        """
+        Set dynamic options for execution providers.
+
+        :param options: Dictionary of key-value pairs where both keys and values are strings.
+                        These options will be passed to the execution providers to modify
+                        their runtime behavior.
+        """
+        self._sess.set_ep_dynamic_options(options)
+
     def get_tuning_results(self):
         return self._sess.get_tuning_results()
 
diff --git a/onnxruntime/python/onnxruntime_pybind_state.cc b/onnxruntime/python/onnxruntime_pybind_state.cc
index c548f3df4fb27..c7ff9e4b5433d 100644
--- a/onnxruntime/python/onnxruntime_pybind_state.cc
+++ b/onnxruntime/python/onnxruntime_pybind_state.cc
@@ -2810,6 +2810,56 @@ including arg name, arg type (contains both type and shape).)pbdoc")
         ORT_THROW("TunableOp and get_tuning_results are not supported in this build.");
 #endif
       })
+      .def(
+          "set_ep_dynamic_options", [](PyInferenceSession* sess, const py::dict& options) -> void {
+            std::vector<const char*> keys;
+            std::vector<const char*> values;
+            std::vector<std::string> key_strings;
+            std::vector<std::string> value_strings;
+
+            // Reserve space to avoid reallocations
+            key_strings.reserve(options.size());
+            value_strings.reserve(options.size());
+            keys.reserve(options.size());
+            values.reserve(options.size());
+
+            // Convert Python dict to C-style arrays
+            for (const auto& item : options) {
+              key_strings.emplace_back(py::str(item.first));
+              value_strings.emplace_back(py::str(item.second));
+              keys.push_back(key_strings.back().c_str());
+              values.push_back(value_strings.back().c_str());
+            }
+
+            if (keys.empty()) {
+              throw std::runtime_error("No options were provided");
+            }
+
+            // Call the underlying C++ method
+            auto status = sess->GetSessionHandle()->SetEpDynamicOptions(
+                gsl::make_span(keys.data(), keys.size()),
+                gsl::make_span(values.data(), values.size()));
+
+            if (!status.IsOK()) {
+              throw std::runtime_error("Failed to set EP dynamic options: " + status.ErrorMessage());
+            }
+          },
+          R"pbdoc(Set dynamic options for execution providers.
+
+          Args:
+              options (dict): Dictionary of key-value pairs where both keys and values are strings.
+                            These options will be passed to the execution providers to modify
+                            their runtime behavior.
+
+          Example:
+              session.set_ep_dynamic_options({
+                  "option1": "value1",
+                  "option2": "value2"
+              })
+
+          Raises:
+              RuntimeError: If no options are provided or if setting the options fails.
+          )pbdoc")
       .def("set_tuning_results", [](PyInferenceSession* sess, py::list results, bool error_on_invalid) -> void {
 #if !defined(ORT_MINIMAL_BUILD)
         std::vector<TuningResults> tuning_results;