diff --git a/prometheus_client/metrics.py b/prometheus_client/metrics.py
index b9f25ffc..39daac2d 100644
--- a/prometheus_client/metrics.py
+++ b/prometheus_client/metrics.py
@@ -203,6 +203,39 @@ def remove(self, *labelvalues: Any) -> None:
             if labelvalues in self._metrics:
                 del self._metrics[labelvalues]
 
+    def remove_by_labels(self, labels: dict[str, str]) -> None:
+        """Remove all series whose labelset partially matches the given labels."""
+        if 'prometheus_multiproc_dir' in os.environ or 'PROMETHEUS_MULTIPROC_DIR' in os.environ:
+            warnings.warn(
+                "Removal of labels has not been implemented in  multi-process mode yet.",
+                UserWarning
+            )
+
+        if not self._labelnames:
+            raise ValueError('No label names were set when constructing %s' % self)
+        
+        if not isinstance(labels, dict):
+            raise TypeError("labels must be a dict of {label_name: label_value}")
+    
+        if not labels:
+            return  # no operation
+    
+        invalid = [k for k in labels.keys() if k not in self._labelnames]
+        if invalid:
+            raise ValueError(
+                'Unknown label names: %s; expected %s' % (invalid, self._labelnames)
+            )
+        
+        pos_filter = {self._labelnames.index(k): str(v) for k, v in labels.items()}
+
+        with self._lock:
+            # list(...) to avoid "dictionary changed size during iteration"
+            for lv in list(self._metrics.keys()):
+                if all(lv[pos] == want for pos, want in pos_filter.items()):
+                    # pop with default avoids KeyError if concurrently removed
+                    self._metrics.pop(lv, None)
+        
+
     def clear(self) -> None:
         """Remove all labelsets from the metric"""
         if 'prometheus_multiproc_dir' in os.environ or 'PROMETHEUS_MULTIPROC_DIR' in os.environ:
diff --git a/tests/test_core.py b/tests/test_core.py
index 284bce09..c7c9c14f 100644
--- a/tests/test_core.py
+++ b/tests/test_core.py
@@ -630,6 +630,40 @@ def test_labels_coerced_to_string(self):
         self.counter.remove(None)
         self.assertEqual(None, self.registry.get_sample_value('c_total', {'l': 'None'}))
 
+    def test_remove_by_labels(self):
+        from prometheus_client import Counter
+
+        c = Counter('c2', 'help', ['tenant', 'endpoint'], registry=self.registry)
+        c.labels('acme', '/').inc()
+        c.labels('acme', '/checkout').inc()
+        c.labels('globex', '/').inc()
+
+        ret = c.remove_by_labels({'tenant': 'acme'})
+        self.assertIsNone(ret)
+
+        self.assertIsNone(self.registry.get_sample_value('c2_total', {'tenant': 'acme', 'endpoint': '/'}))
+        self.assertIsNone(self.registry.get_sample_value('c2_total', {'tenant': 'acme', 'endpoint': '/checkout'}))
+        self.assertEqual(1, self.registry.get_sample_value('c2_total', {'tenant': 'globex', 'endpoint': '/'}))
+
+
+    def test_remove_by_labels_invalid_label_name(self):
+        from prometheus_client import Counter
+        c = Counter('c3', 'help', ['tenant', 'endpoint'], registry=self.registry)
+        c.labels('acme', '/').inc()
+        with self.assertRaises(ValueError):
+            c.remove_by_labels({'badkey': 'x'})
+
+
+    def test_remove_by_labels_empty_is_noop(self):
+        from prometheus_client import Counter
+        c = Counter('c4', 'help', ['tenant', 'endpoint'], registry=self.registry)
+        c.labels('acme', '/').inc()
+
+        ret = c.remove_by_labels({})
+        self.assertIsNone(ret)
+        # Ensure the series is still present
+        self.assertEqual(1, self.registry.get_sample_value('c4_total', {'tenant': 'acme', 'endpoint': '/'}))
+        
     def test_non_string_labels_raises(self):
         class Test:
             __str__ = None