diff --git a/src/coreclr/jit/gentree.cpp b/src/coreclr/jit/gentree.cpp
index 8ba61fe3a1121c..a73fb77b6bae7d 100644
--- a/src/coreclr/jit/gentree.cpp
+++ b/src/coreclr/jit/gentree.cpp
@@ -30360,8 +30360,11 @@ GenTree* Compiler::gtFoldExprHWIntrinsic(GenTreeHWIntrinsic* tree)
 #endif // !TARGET_XARCH && !TARGET_ARM64
 
                     DEBUG_DESTROY_NODE(op, tree);
-                    INDEBUG(vectorNode->gtDebugFlags |= GTF_DEBUG_NODE_MORPHED);
 
+                    if (fgGlobalMorph)
+                    {
+                        INDEBUG(vectorNode->gtDebugFlags |= GTF_DEBUG_NODE_MORPHED);
+                    }
                     return vectorNode;
                 }
             }
diff --git a/src/coreclr/jit/lowerxarch.cpp b/src/coreclr/jit/lowerxarch.cpp
index 8b199a898d4419..3f441215e37123 100644
--- a/src/coreclr/jit/lowerxarch.cpp
+++ b/src/coreclr/jit/lowerxarch.cpp
@@ -1570,6 +1570,21 @@ GenTree* Lowering::LowerHWIntrinsic(GenTreeHWIntrinsic* node)
                                     op2->SetUnusedValue();
                                 }
 
+                                // Since we have a double negation, it's possible that gtNext
+                                // is op1 or user. If it is op1, then it's also possible the
+                                // subsequent gtNext is user. We need to make sure to skip both
+                                // in such a scenario since we're removing them.
+
+                                if (nextNode == op1)
+                                {
+                                    nextNode = nextNode->gtNext;
+                                }
+
+                                if (nextNode == user)
+                                {
+                                    nextNode = nextNode->gtNext;
+                                }
+
                                 BlockRange().Remove(op3);
                                 BlockRange().Remove(op1);
                                 BlockRange().Remove(user);
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_105255/Runtime_105255.cs b/src/tests/JIT/Regression/JitBlue/Runtime_105255/Runtime_105255.cs
new file mode 100644
index 00000000000000..bee31e60b12003
--- /dev/null
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_105255/Runtime_105255.cs
@@ -0,0 +1,36 @@
+// Licensed to the .NET Foundation under one or more agreements.
+// The .NET Foundation licenses this file to you under the MIT license.
+
+using System.Runtime.CompilerServices;
+using System.Runtime.Intrinsics;
+using Xunit;
+
+#nullable disable
+
+public class Runtime_105255_A
+{
+    private static Vector512<uint> s_v512_uint_62 = Vector512<uint>.Zero;
+
+    private void Method0()
+    {
+        s_v512_uint_62 = Vector512.LessThan<uint>(s_v512_uint_62, Vector512<uint>.Zero);
+        try
+        {
+        }
+        finally
+        {
+            for (int i = 0; i < 1; i++) ;
+        }
+    }
+
+    [Fact]
+    public static void TestEntryPoint() => new Runtime_105255_A().Method0();
+
+    /*
+    Assert failure(PID 5828 [0x000016c4], Thread: 6044 [0x179c]): Assertion failed '((tree->gtDebugFlags & GTF_DEBUG_NODE_MORPHED) == 0) && "ERROR: Already morphed this node!"' in 'TestClass:Method0():this' during 'Morph - Global' (IL size 22846; hash 0x46e9aa75; Tier0-FullOpts)
+        File: D:\a\_work\1\s\src\coreclr\jit\morph.cpp:12227
+        Image: C:\h\w\A715090A\p\CoreRoot\corerun.exe
+
+    Assertion failed '((tree->gtDebugFlags & GTF_DEBUG_NODE_MORPHED) == 0) && "ERROR: Already morphed this node!"' during 'Morph - Global'
+    */
+}
diff --git a/src/tests/JIT/Regression/JitBlue/Runtime_105255/Runtime_105255.csproj b/src/tests/JIT/Regression/JitBlue/Runtime_105255/Runtime_105255.csproj
new file mode 100644
index 00000000000000..de6d5e08882e86
--- /dev/null
+++ b/src/tests/JIT/Regression/JitBlue/Runtime_105255/Runtime_105255.csproj
@@ -0,0 +1,8 @@
+<Project Sdk="Microsoft.NET.Sdk">
+  <PropertyGroup>
+    <Optimize>True</Optimize>
+  </PropertyGroup>
+  <ItemGroup>
+    <Compile Include="$(MSBuildProjectName).cs" />
+  </ItemGroup>
+</Project>