diff --git a/src/coreclr/jit/lowerxarch.cpp b/src/coreclr/jit/lowerxarch.cpp
index 51b11fc089cf19..498e0fe936aa4d 100644
--- a/src/coreclr/jit/lowerxarch.cpp
+++ b/src/coreclr/jit/lowerxarch.cpp
@@ -7696,7 +7696,7 @@ void Lowering::ContainCheckCallOperands(GenTreeCall* call)
         }
         else
 #endif // TARGET_X86
-            if (ctrlExpr->isIndir())
+            if (ctrlExpr->isIndir() && IsSafeToContainMem(call, ctrlExpr))
             {
                 // We may have cases where we have set a register target on the ctrlExpr, but if it
                 // contained we must clear it.