diff --git a/CHANGELOG.md b/CHANGELOG.md
index 550ebac042..a9adceeed1 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -15,6 +15,7 @@
 - Custom ISentryEventProcessors are now run for native iOS events ([#4318](https://github.com/getsentry/sentry-dotnet/pull/4318))
 - Crontab validation when capturing checkins ([#4314](https://github.com/getsentry/sentry-dotnet/pull/4314))
 - Native AOT: link to static `lzma` on Linux/MUSL ([#4326](https://github.com/getsentry/sentry-dotnet/pull/4326))
+- AppDomain.CurrentDomain.ProcessExit hook is now removed on shutdown ([#4323](https://github.com/getsentry/sentry-dotnet/pull/4323))
 
 ### Dependencies
 
diff --git a/src/Sentry/Integrations/AppDomainProcessExitIntegration.cs b/src/Sentry/Integrations/AppDomainProcessExitIntegration.cs
index 9fd9caebe2..07b222b4dd 100644
--- a/src/Sentry/Integrations/AppDomainProcessExitIntegration.cs
+++ b/src/Sentry/Integrations/AppDomainProcessExitIntegration.cs
@@ -3,7 +3,7 @@
 
 namespace Sentry.Integrations;
 
-internal class AppDomainProcessExitIntegration : ISdkIntegration
+internal class AppDomainProcessExitIntegration : ISdkIntegration, IDisposable
 {
     private readonly IAppDomain _appDomain;
     private IHub? _hub;
@@ -24,4 +24,9 @@ internal void HandleProcessExit(object? sender, EventArgs e)
         _options?.LogInfo("AppDomain process exited: Disposing SDK.");
         (_hub as IDisposable)?.Dispose();
     }
+
+    public void Dispose()
+    {
+        _appDomain.ProcessExit -= HandleProcessExit;
+    }
 }
diff --git a/src/Sentry/Internal/Hub.cs b/src/Sentry/Internal/Hub.cs
index ff9d5de43a..67318abc54 100644
--- a/src/Sentry/Internal/Hub.cs
+++ b/src/Sentry/Internal/Hub.cs
@@ -1,5 +1,6 @@
 using Sentry.Extensibility;
 using Sentry.Infrastructure;
+using Sentry.Integrations;
 using Sentry.Protocol.Envelopes;
 using Sentry.Protocol.Metrics;
 
@@ -14,6 +15,7 @@ internal class Hub : IHub, IDisposable
     private readonly SentryOptions _options;
     private readonly RandomValuesFactory _randomValuesFactory;
     private readonly IReplaySession _replaySession;
+    private readonly List<IDisposable> _integrationsToCleanup = new();
 
 #if MEMORY_DUMP_SUPPORTED
     private readonly MemoryMonitor? _memoryMonitor;
@@ -84,6 +86,10 @@ internal Hub(
         {
             options.LogDebug("Registering integration: '{0}'.", integration.GetType().Name);
             integration.Register(this, options);
+            if (integration is IDisposable disposableIntegration)
+            {
+                _integrationsToCleanup.Add(disposableIntegration);
+            }
         }
     }
 
@@ -772,6 +778,18 @@ public void Dispose()
             return;
         }
 
+        foreach (var integration in _integrationsToCleanup)
+        {
+            try
+            {
+                integration.Dispose();
+            }
+            catch (Exception e)
+            {
+                _options.LogError("Failed to dispose integration {0}: {1}", integration.GetType().Name, e);
+            }
+        }
+
 #if MEMORY_DUMP_SUPPORTED
         _memoryMonitor?.Dispose();
 #endif
diff --git a/test/Sentry.Tests/HubTests.cs b/test/Sentry.Tests/HubTests.cs
index 864a92dd2d..85bf533df9 100644
--- a/test/Sentry.Tests/HubTests.cs
+++ b/test/Sentry.Tests/HubTests.cs
@@ -1988,6 +1988,100 @@ public void CaptureUserFeedback_InvalidEmail_FeedbackDropped(string email)
         _fixture.Client.Received(1).CaptureUserFeedback(Arg.Is<UserFeedback>(f => f.Email.IsNull()));
 #pragma warning restore CS0618 // Type or member is obsolete
     }
+
+    private class TestDisposableIntegration : ISdkIntegration, IDisposable
+    {
+        public int Registered { get; private set; }
+        public int Disposed { get; private set; }
+
+        public void Register(IHub hub, SentryOptions options)
+        {
+            Registered++;
+        }
+
+        protected virtual void Cleanup()
+        {
+            Disposed++;
+        }
+
+        public void Dispose()
+        {
+            Cleanup();
+        }
+    }
+
+    private class TestFlakyDisposableIntegration : TestDisposableIntegration
+    {
+        protected override void Cleanup()
+        {
+            throw new InvalidOperationException("Cleanup failed");
+        }
+    }
+
+    [Fact]
+    public void Dispose_IntegrationsWithCleanup_CleanupCalled()
+    {
+        // Arrange
+        var integration1 = new TestDisposableIntegration();
+        var integration2 = Substitute.For<ISdkIntegration>();
+        var integration3 = new TestDisposableIntegration();
+        _fixture.Options.AddIntegration(integration1);
+        _fixture.Options.AddIntegration(integration2);
+        _fixture.Options.AddIntegration(integration3);
+        var hub = _fixture.GetSut();
+
+        // Act
+        hub.Dispose();
+
+        // Assert
+        integration1.Disposed.Should().Be(1);
+        integration3.Disposed.Should().Be(1);
+    }
+
+    [Fact]
+    public void Dispose_CleanupThrowsException_ExceptionHandledAndLogged()
+    {
+        // Arrange
+        var integration1 = new TestDisposableIntegration();
+        var integration2 = new TestFlakyDisposableIntegration();
+        var integration3 = new TestDisposableIntegration();
+        _fixture.Options.AddIntegration(integration1);
+        _fixture.Options.AddIntegration(integration2);
+        _fixture.Options.AddIntegration(integration3);
+        _fixture.Options.Debug = true;
+        _fixture.Options.DiagnosticLogger = Substitute.For<IDiagnosticLogger>();
+        _fixture.Options.DiagnosticLogger!.IsEnabled(Arg.Any<SentryLevel>()).Returns(true);
+        var hub = _fixture.GetSut();
+
+        // Act
+        hub.Dispose();
+
+        // Assert
+        integration1.Disposed.Should().Be(1);
+        integration2.Disposed.Should().Be(0);
+        integration3.Disposed.Should().Be(1);
+        _fixture.Options.DiagnosticLogger.Received(1).Log(
+            SentryLevel.Error,
+            Arg.Is<string>(s => s.Contains("Failed to dispose integration")),
+            Arg.Any<InvalidOperationException>(),
+            Arg.Any<object[]>());
+    }
+
+    [Fact]
+    public void Dispose_CalledMultipleTimes_CleanupCalledOnlyOnce()
+    {
+        // Arrange
+        var integration = new TestDisposableIntegration();
+        _fixture.Options.AddIntegration(integration);
+        var hub = _fixture.GetSut();
+
+        // Act
+        hub.Dispose();
+        hub.Dispose();
+
+        // Assert
+        integration.Disposed.Should().Be(1);
+    }
 }
 
 #if NET6_0_OR_GREATER