diff --git a/.github/workflows/e2e-v2.yml b/.github/workflows/e2e-v2.yml
index c18eaabae2..ade224968b 100644
--- a/.github/workflows/e2e-v2.yml
+++ b/.github/workflows/e2e-v2.yml
@@ -163,7 +163,7 @@ jobs:
     strategy:
       fail-fast: false # keeps matrix running if one fails
       matrix:
-        rn-version: ['0.65.3', '0.79.1']
+        rn-version: ['0.65.3', '0.80.0']
         rn-architecture: ['legacy', 'new']
         platform: ['android', 'ios']
         build-type: ['production']
@@ -171,7 +171,7 @@ jobs:
         engine: ['hermes', 'jsc']
         include:
           - platform: ios
-            rn-version: '0.79.1'
+            rn-version: '0.80.0'
             xcode-version: '16.2'
             runs-on: macos-15
           - platform: ios
@@ -182,7 +182,7 @@ jobs:
             runs-on: ubuntu-latest
         exclude:
           # exclude JSC for new RN versions (keeping the matrix manageable)
-          - rn-version: '0.79.1'
+          - rn-version: '0.80.0'
             engine: 'jsc'
           # exclude all rn versions lower than 0.70.0 for new architecture
           - rn-version: '0.65.3'
@@ -301,7 +301,7 @@ jobs:
     strategy:
       fail-fast: false # keeps matrix running if one fails
       matrix:
-        rn-version: ['0.65.3', '0.79.1']
+        rn-version: ['0.65.3', '0.80.0']
         rn-architecture: ['legacy', 'new']
         platform: ['android', 'ios']
         build-type: ['production']
@@ -309,7 +309,7 @@ jobs:
         engine: ['hermes', 'jsc']
         include:
           - platform: ios
-            rn-version: '0.79.1'
+            rn-version: '0.80.0'
             runs-on: macos-15
           - platform: ios
             rn-version: '0.65.3'
@@ -323,7 +323,7 @@ jobs:
           # e2e test only the default combinations
           - rn-version: '0.65.3'
             engine: 'hermes'
-          - rn-version: '0.79.1'
+          - rn-version: '0.80.0'
             engine: 'jsc'
 
     steps:
diff --git a/CHANGELOG.md b/CHANGELOG.md
index ff23fffc07..d5408b8e81 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -30,6 +30,7 @@
 
 ### Fixes
 
+- Adds support for React Native 0.80 ([#4938](https://github.com/getsentry/sentry-react-native/pull/4938))
 - Report slow and frozen frames as app start span data ([#4865](https://github.com/getsentry/sentry-react-native/pull/4865))
 - User set by `Sentry.setUser` is prefilled in Feedback Widget ([#4901](https://github.com/getsentry/sentry-react-native/pull/4901))
   - User data are considered from all scopes in the following order current, isolation and global.
diff --git a/dev-packages/e2e-tests/cli.mjs b/dev-packages/e2e-tests/cli.mjs
index c9281549f3..9d8f958b80 100755
--- a/dev-packages/e2e-tests/cli.mjs
+++ b/dev-packages/e2e-tests/cli.mjs
@@ -68,6 +68,25 @@ const testApp = `${e2eDir}/${testAppName}`;
 const appId = platform === 'ios' ? 'org.reactjs.native.example.RnDiffApp' : 'com.rndiffapp';
 const sentryAuthToken = env.SENTRY_AUTH_TOKEN;
 
+function runCodegenIfNeeded(rnVersion, platform, appDir) {
+  const versionNumber = parseFloat(rnVersion.replace(/[^\d.]/g, ''));
+  const shouldRunCodegen = platform === 'android' && versionNumber >= 0.80;
+
+  if (shouldRunCodegen) {
+    console.log(`Running codegen for React Native ${rnVersion}...`);
+    try {
+      execSync('./gradlew generateCodegenArtifactsFromSchema', {
+        stdio: 'inherit',
+        cwd: path.join(appDir, 'android'),
+        env: env
+      });
+      console.log('Gradle codegen task completed successfully');
+    } catch (error) {
+      console.error('Codegen failed:', error.message);
+    }
+  }
+}
+
 // Build and publish the SDK - we only need to do this once in CI.
 // Locally, we may want to get updates from the latest build so do it on every app build.
 if (actions.includes('create') || (env.CI === undefined && actions.includes('build'))) {
@@ -198,6 +217,8 @@ if (actions.includes('build')) {
 
     appProduct = `${appDir}/ios/DerivedData/Build/Products/${buildType}-iphonesimulator/${appName}.app`;
   } else if (platform == 'android') {
+    runCodegenIfNeeded(RNVersion, platform, appDir);
+
     execSync(`./gradlew assemble${buildType} -PreactNativeArchitectures=x86 --no-daemon`, {
       stdio: 'inherit',
       cwd: `${appDir}/android`,
diff --git a/dev-packages/e2e-tests/patch-scripts/rn.patch.app.js b/dev-packages/e2e-tests/patch-scripts/rn.patch.app.js
index ec6b3f5262..3fd9f5f825 100755
--- a/dev-packages/e2e-tests/patch-scripts/rn.patch.app.js
+++ b/dev-packages/e2e-tests/patch-scripts/rn.patch.app.js
@@ -41,7 +41,8 @@ Sentry.init({
 const e2eComponentPatch = '<EndToEndTestsScreen />';
 const lastImportRex = /^([^]*)(import\s+[^;]*?;$)/m;
 const patchRex = '@sentry/react-native';
-const headerComponentRex = /<ScrollView/gm;
+// Support both older RN versions with ScrollView and newer versions with NewAppScreen
+const headerComponentRex = /(<ScrollView|<NewAppScreen)/gm;
 const exportDefaultRex = /export\s+default\s+App;/m;
 
 const jsPath = path.join(args.app, 'App.js');
diff --git a/packages/core/RNSentry.podspec b/packages/core/RNSentry.podspec
index 2ad70ce371..c5fde1f876 100644
--- a/packages/core/RNSentry.podspec
+++ b/packages/core/RNSentry.podspec
@@ -7,8 +7,15 @@ rn_version = get_rn_version(rn_package)
 is_hermes_default = is_hermes_default(rn_version)
 is_profiling_supported = is_profiling_supported(rn_version)
 
-folly_flags = ' -DFOLLY_NO_CONFIG -DFOLLY_MOBILE=1 -DFOLLY_USE_LIBCPP=1'
-folly_compiler_flags = folly_flags + ' ' + '-Wno-comma -Wno-shorten-64-to-32'
+# Use different Folly configuration for RN 0.80.0+
+if should_use_folly_flags(rn_version)
+  # For older RN versions, keep the original Folly configuration
+  folly_flags = ' -DFOLLY_NO_CONFIG -DFOLLY_MOBILE=1 -DFOLLY_USE_LIBCPP=1'
+  folly_compiler_flags = folly_flags + ' ' + '-Wno-comma -Wno-shorten-64-to-32'
+else
+  # For RN 0.80+, don't use the incompatible Folly flags
+  folly_compiler_flags = ''
+end
 
 is_new_arch_enabled = ENV["RCT_NEW_ARCH_ENABLED"] == "1"
 is_using_hermes = (ENV['USE_HERMES'] == nil && is_hermes_default) || ENV['USE_HERMES'] == '1'
diff --git a/packages/core/scripts/sentry_utils.rb b/packages/core/scripts/sentry_utils.rb
index c5a8158c4d..fd788486b0 100644
--- a/packages/core/scripts/sentry_utils.rb
+++ b/packages/core/scripts/sentry_utils.rb
@@ -31,3 +31,8 @@ def is_hermes_default(rn_version)
 def is_profiling_supported(rn_version)
   return (rn_version[:major] >= 1 || (rn_version[:major] == 0 && rn_version[:minor] >= 69))
 end
+
+# Check if we need the old Folly flags (for RN < 0.80.0)
+def should_use_folly_flags(rn_version)
+  return (rn_version[:major] == 0 && rn_version[:minor] < 80)
+end