diff --git a/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/code/CompileQueue.java b/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/code/CompileQueue.java
index 845f878b3f55..9f91009a9435 100644
--- a/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/code/CompileQueue.java
+++ b/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/code/CompileQueue.java
@@ -990,7 +990,7 @@ private static boolean parseInCurrentLayer(HostedMethod method) {
             SVMImageLayerLoader imageLayerLoader = HostedImageLayerBuildingSupport.singleton().getLoader();
             hasAnalyzedGraph = imageLayerLoader.hasStrengthenedGraph(method.wrapped);
         }
-        assert hasAnalyzedGraph || method.isCompiledInPriorLayer() || method.compilationInfo.inParseQueue.get() : method;
+        assert hasAnalyzedGraph || !method.wrapped.reachableInCurrentLayer() || method.isCompiledInPriorLayer() || method.compilationInfo.inParseQueue.get() : method;
         return hasAnalyzedGraph;
     }
 
@@ -1205,6 +1205,19 @@ protected void ensureCompiled(HostedMethod method, CompileReason reason) {
              */
             return;
         }
+        if (ImageLayerBuildingSupport.buildingExtensionLayer() && !method.wrapped.reachableInCurrentLayer()) {
+            assert method.wrapped.isInBaseLayer();
+            /*
+             * This method was reached and analyzed in the base layer, but it was not compiled in
+             * that layer, e.g., because it was always inlined. It is referenced in the app layer,
+             * but it was not reached during this layer's analysis, so its base layer graph was not
+             * loaded. However, it is considered as a potential compilation target because it is the
+             * implementation of a method invoked in this layer. Since we don't have an analysis
+             * graph we cannot compile it, however it should not be called at run time since it was
+             * not reached during analysis. (GR-64200)
+             */
+            return;
+        }
 
         CompilationInfo compilationInfo = method.compilationInfo;
         assert method.getMultiMethodKey() != SubstrateCompilationDirectives.RUNTIME_COMPILED_METHOD;
diff --git a/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/imagelayer/SVMImageLayerLoader.java b/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/imagelayer/SVMImageLayerLoader.java
index fd08937c6fab..c75e48ef605c 100644
--- a/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/imagelayer/SVMImageLayerLoader.java
+++ b/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/imagelayer/SVMImageLayerLoader.java
@@ -54,12 +54,7 @@
 import java.util.stream.Stream;
 import java.util.stream.StreamSupport;
 
-import com.oracle.svm.shaded.org.capnproto.ListReader;
-import com.oracle.svm.shaded.org.capnproto.PrimitiveList;
-import com.oracle.svm.shaded.org.capnproto.StructList;
-import com.oracle.svm.shaded.org.capnproto.StructReader;
-import com.oracle.svm.shaded.org.capnproto.Text;
-import com.oracle.svm.shaded.org.capnproto.TextList;
+import org.graalvm.nativeimage.AnnotationAccess;
 import org.graalvm.nativeimage.ImageSingletons;
 import org.graalvm.nativeimage.c.function.CEntryPoint;
 import org.graalvm.nativeimage.impl.CEntryPointLiteralCodePointer;
@@ -87,6 +82,7 @@
 import com.oracle.graal.pointsto.util.AnalysisFuture;
 import com.oracle.graal.pointsto.util.CompletionExecutor.DebugContextRunnable;
 import com.oracle.svm.core.SubstrateOptions;
+import com.oracle.svm.core.annotate.Delete;
 import com.oracle.svm.core.classinitialization.ClassInitializationInfo;
 import com.oracle.svm.core.graal.code.CGlobalDataInfo;
 import com.oracle.svm.core.hub.DynamicHub;
@@ -124,6 +120,12 @@
 import com.oracle.svm.hosted.reflect.ReflectionFeature;
 import com.oracle.svm.hosted.reflect.serialize.SerializationFeature;
 import com.oracle.svm.hosted.util.IdentityHashCodeUtil;
+import com.oracle.svm.shaded.org.capnproto.ListReader;
+import com.oracle.svm.shaded.org.capnproto.PrimitiveList;
+import com.oracle.svm.shaded.org.capnproto.StructList;
+import com.oracle.svm.shaded.org.capnproto.StructReader;
+import com.oracle.svm.shaded.org.capnproto.Text;
+import com.oracle.svm.shaded.org.capnproto.TextList;
 import com.oracle.svm.util.LogUtils;
 import com.oracle.svm.util.ReflectionUtil;
 
@@ -1536,7 +1538,7 @@ private JavaConstant lookupHostedObject(PersistedConstant.Reader baseLayerConsta
         } else if (relinking.isFieldConstant()) {
             var fieldConstant = relinking.getFieldConstant();
             AnalysisField analysisField = getAnalysisFieldForBaseLayerId(fieldConstant.getOriginFieldId());
-            if (!(analysisField.getWrapped() instanceof BaseLayerField)) {
+            if (!(analysisField.getWrapped() instanceof BaseLayerField) && !AnnotationAccess.isAnnotationPresent(analysisField, Delete.class)) {
                 VMError.guarantee(!baseLayerConstant.getIsSimulated(), "Should not alter the initialization status for simulated constants.");
                 /*
                  * The declaring type of relinked fields was already initialized in the previous
diff --git a/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/imagelayer/SVMImageLayerWriter.java b/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/imagelayer/SVMImageLayerWriter.java
index 634545ac58f8..5d6870f3e48f 100644
--- a/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/imagelayer/SVMImageLayerWriter.java
+++ b/substratevm/src/com.oracle.svm.hosted/src/com/oracle/svm/hosted/imagelayer/SVMImageLayerWriter.java
@@ -67,15 +67,6 @@
 import java.util.stream.IntStream;
 import java.util.stream.Stream;
 
-import com.oracle.svm.shaded.org.capnproto.ListBuilder;
-import com.oracle.svm.shaded.org.capnproto.MessageBuilder;
-import com.oracle.svm.shaded.org.capnproto.PrimitiveList;
-import com.oracle.svm.shaded.org.capnproto.Serialize;
-import com.oracle.svm.shaded.org.capnproto.StructBuilder;
-import com.oracle.svm.shaded.org.capnproto.StructList;
-import com.oracle.svm.shaded.org.capnproto.Text;
-import com.oracle.svm.shaded.org.capnproto.TextList;
-import com.oracle.svm.shaded.org.capnproto.Void;
 import org.graalvm.collections.EconomicMap;
 import org.graalvm.collections.MapCursor;
 import org.graalvm.nativeimage.AnnotationAccess;
@@ -104,6 +95,7 @@
 import com.oracle.svm.core.FunctionPointerHolder;
 import com.oracle.svm.core.StaticFieldsSupport;
 import com.oracle.svm.core.SubstrateOptions;
+import com.oracle.svm.core.annotate.Delete;
 import com.oracle.svm.core.classinitialization.ClassInitializationInfo;
 import com.oracle.svm.core.graal.code.CGlobalDataBasePointer;
 import com.oracle.svm.core.hub.DynamicHub;
@@ -158,6 +150,15 @@
 import com.oracle.svm.hosted.reflect.proxy.ProxySubstitutionType;
 import com.oracle.svm.hosted.substitute.PolymorphicSignatureWrapperMethod;
 import com.oracle.svm.hosted.substitute.SubstitutionMethod;
+import com.oracle.svm.shaded.org.capnproto.ListBuilder;
+import com.oracle.svm.shaded.org.capnproto.MessageBuilder;
+import com.oracle.svm.shaded.org.capnproto.PrimitiveList;
+import com.oracle.svm.shaded.org.capnproto.Serialize;
+import com.oracle.svm.shaded.org.capnproto.StructBuilder;
+import com.oracle.svm.shaded.org.capnproto.StructList;
+import com.oracle.svm.shaded.org.capnproto.Text;
+import com.oracle.svm.shaded.org.capnproto.TextList;
+import com.oracle.svm.shaded.org.capnproto.Void;
 import com.oracle.svm.util.FileDumpingUtil;
 import com.oracle.svm.util.LogUtils;
 import com.oracle.svm.util.ModuleSupport;
@@ -867,7 +868,8 @@ private boolean shouldRelinkConstant(ImageHeapConstant heapConstant) {
     }
 
     private static boolean shouldRelinkField(AnalysisField field) {
-        return ClassInitializationSupport.singleton().maybeInitializeAtBuildTime(field.getDeclaringClass()) &&
+        return !AnnotationAccess.isAnnotationPresent(field, Delete.class) &&
+                        ClassInitializationSupport.singleton().maybeInitializeAtBuildTime(field.getDeclaringClass()) &&
                         field.isStatic() && field.isFinal() && field.isTrackedAcrossLayers() && field.installableInLayer();
     }