diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=14336,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=14336,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json
new file mode 100644
index 000000000000..b6f1d01f8865
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=14336,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json
@@ -0,0 +1,164 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "16": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "24": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "32": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "48": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "64": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "96": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "128": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "256": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "512": {
+        "BLOCK_SIZE_M": 256,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "1024": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "1536": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "2048": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "3072": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "4096": {
+        "BLOCK_SIZE_M": 256,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    }
+}
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=14336,device_name=AMD_Instinct_MI300X.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=14336,device_name=AMD_Instinct_MI300X.json
index 4d4b752fa5d6..66f9106bd1be 100644
--- a/vllm/model_executor/layers/fused_moe/configs/E=8,N=14336,device_name=AMD_Instinct_MI300X.json
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=14336,device_name=AMD_Instinct_MI300X.json
@@ -1,21 +1,21 @@
 {
     "1": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_N": 16,
         "BLOCK_SIZE_K": 256,
         "GROUP_SIZE_M": 1,
         "num_warps": 2,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "2": {
         "BLOCK_SIZE_M": 16,
         "BLOCK_SIZE_N": 16,
-        "BLOCK_SIZE_K": 128,
+        "BLOCK_SIZE_K": 256,
         "GROUP_SIZE_M": 1,
-        "num_warps": 2,
+        "num_warps": 4,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
@@ -23,10 +23,10 @@
     },
     "4": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 32,
-        "BLOCK_SIZE_K": 256,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 128,
         "GROUP_SIZE_M": 1,
-        "num_warps": 2,
+        "num_warps": 1,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
@@ -34,10 +34,10 @@
     },
     "8": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 16,
-        "BLOCK_SIZE_K": 256,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
         "GROUP_SIZE_M": 1,
-        "num_warps": 1,
+        "num_warps": 2,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
@@ -48,7 +48,7 @@
         "BLOCK_SIZE_N": 16,
         "BLOCK_SIZE_K": 256,
         "GROUP_SIZE_M": 1,
-        "num_warps": 4,
+        "num_warps": 2,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
@@ -56,10 +56,10 @@
     },
     "24": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 32,
-        "BLOCK_SIZE_K": 64,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
         "GROUP_SIZE_M": 1,
-        "num_warps": 1,
+        "num_warps": 2,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
@@ -67,32 +67,32 @@
     },
     "32": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 16,
-        "BLOCK_SIZE_K": 128,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 256,
         "GROUP_SIZE_M": 4,
         "num_warps": 2,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "48": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_N": 64,
         "BLOCK_SIZE_K": 128,
         "GROUP_SIZE_M": 4,
-        "num_warps": 2,
+        "num_warps": 4,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 2
+        "kpack": 1
     },
     "64": {
         "BLOCK_SIZE_M": 32,
         "BLOCK_SIZE_N": 64,
         "BLOCK_SIZE_K": 128,
         "GROUP_SIZE_M": 4,
-        "num_warps": 8,
+        "num_warps": 4,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
@@ -100,24 +100,24 @@
     },
     "96": {
         "BLOCK_SIZE_M": 32,
-        "BLOCK_SIZE_N": 32,
-        "BLOCK_SIZE_K": 128,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
         "GROUP_SIZE_M": 4,
-        "num_warps": 4,
+        "num_warps": 8,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 2
+        "kpack": 1
     },
     "128": {
         "BLOCK_SIZE_M": 64,
         "BLOCK_SIZE_N": 64,
-        "BLOCK_SIZE_K": 64,
+        "BLOCK_SIZE_K": 128,
         "GROUP_SIZE_M": 4,
-        "num_warps": 8,
+        "num_warps": 4,
         "num_stages": 2,
         "waves_per_eu": 0,
-        "matrix_instr_nonkdim": 16,
+        "matrix_instr_nonkdim": 32,
         "kpack": 2
     },
     "256": {
@@ -129,7 +129,7 @@
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "512": {
         "BLOCK_SIZE_M": 128,
@@ -150,7 +150,7 @@
         "num_warps": 8,
         "num_stages": 2,
         "waves_per_eu": 0,
-        "matrix_instr_nonkdim": 32,
+        "matrix_instr_nonkdim": 16,
         "kpack": 2
     },
     "1536": {
@@ -184,7 +184,7 @@
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "4096": {
         "BLOCK_SIZE_M": 128,
@@ -195,6 +195,6 @@
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     }
 }
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=16384,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=16384,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json
new file mode 100644
index 000000000000..0e5fd1eec77d
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=16384,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json
@@ -0,0 +1,164 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "16": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "24": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "32": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "48": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "64": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "96": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "128": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "256": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "512": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "1024": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "1536": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "2048": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "3072": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "4096": {
+        "BLOCK_SIZE_M": 256,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    }
+}
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=16384,device_name=AMD_Instinct_MI300X.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=16384,device_name=AMD_Instinct_MI300X.json
new file mode 100644
index 000000000000..d6ad63509f15
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=16384,device_name=AMD_Instinct_MI300X.json
@@ -0,0 +1,200 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "16": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 1,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "24": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "32": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "48": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "64": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "96": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "128": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "256": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "512": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "1024": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "1536": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "2048": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "3072": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 16,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "4096": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 16,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    }
+}
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=1792,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=1792,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json
new file mode 100644
index 000000000000..8323f512db01
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=1792,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json
@@ -0,0 +1,164 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "16": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "24": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "32": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "48": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "64": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "96": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "128": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "256": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "512": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "1024": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "1536": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "2048": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "3072": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "4096": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    }
+}
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=1792,device_name=AMD_Instinct_MI300X.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=1792,device_name=AMD_Instinct_MI300X.json
index a218fc40642c..1b46cb571651 100644
--- a/vllm/model_executor/layers/fused_moe/configs/E=8,N=1792,device_name=AMD_Instinct_MI300X.json
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=1792,device_name=AMD_Instinct_MI300X.json
@@ -1,10 +1,10 @@
 {
     "1": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 32,
-        "BLOCK_SIZE_K": 256,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 128,
         "GROUP_SIZE_M": 1,
-        "num_warps": 2,
+        "num_warps": 4,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
@@ -19,14 +19,14 @@
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "4": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_N": 128,
         "BLOCK_SIZE_K": 128,
         "GROUP_SIZE_M": 1,
-        "num_warps": 4,
+        "num_warps": 8,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
@@ -34,76 +34,76 @@
     },
     "8": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 16,
-        "BLOCK_SIZE_K": 256,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
         "GROUP_SIZE_M": 1,
-        "num_warps": 2,
+        "num_warps": 4,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 2
+        "kpack": 1
     },
     "16": {
-        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_M": 16,
         "BLOCK_SIZE_N": 64,
-        "BLOCK_SIZE_K": 64,
+        "BLOCK_SIZE_K": 128,
         "GROUP_SIZE_M": 1,
-        "num_warps": 8,
+        "num_warps": 4,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "24": {
         "BLOCK_SIZE_M": 16,
         "BLOCK_SIZE_N": 64,
-        "BLOCK_SIZE_K": 64,
+        "BLOCK_SIZE_K": 128,
         "GROUP_SIZE_M": 1,
         "num_warps": 4,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "32": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 16,
-        "BLOCK_SIZE_K": 256,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
         "GROUP_SIZE_M": 4,
-        "num_warps": 2,
+        "num_warps": 4,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 2
+        "kpack": 1
     },
     "48": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 128,
-        "BLOCK_SIZE_K": 64,
-        "GROUP_SIZE_M": 1,
-        "num_warps": 8,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 2,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
         "kpack": 2
     },
     "64": {
-        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_M": 32,
         "BLOCK_SIZE_N": 64,
-        "BLOCK_SIZE_K": 64,
+        "BLOCK_SIZE_K": 128,
         "GROUP_SIZE_M": 1,
-        "num_warps": 2,
+        "num_warps": 4,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "96": {
         "BLOCK_SIZE_M": 32,
-        "BLOCK_SIZE_N": 32,
-        "BLOCK_SIZE_K": 256,
-        "GROUP_SIZE_M": 4,
-        "num_warps": 4,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
@@ -112,24 +112,24 @@
     "128": {
         "BLOCK_SIZE_M": 64,
         "BLOCK_SIZE_N": 64,
-        "BLOCK_SIZE_K": 64,
+        "BLOCK_SIZE_K": 128,
         "GROUP_SIZE_M": 4,
         "num_warps": 8,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "256": {
-        "BLOCK_SIZE_M": 128,
-        "BLOCK_SIZE_N": 128,
-        "BLOCK_SIZE_K": 64,
-        "GROUP_SIZE_M": 4,
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
         "num_warps": 8,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "512": {
         "BLOCK_SIZE_M": 64,
@@ -151,7 +151,7 @@
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "1536": {
         "BLOCK_SIZE_M": 128,
@@ -162,7 +162,7 @@
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "2048": {
         "BLOCK_SIZE_M": 128,
@@ -184,7 +184,7 @@
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "4096": {
         "BLOCK_SIZE_M": 128,
@@ -195,6 +195,6 @@
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     }
 }
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=2048,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=2048,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json
new file mode 100644
index 000000000000..81bb765d3003
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=2048,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json
@@ -0,0 +1,164 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "16": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "24": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "32": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "48": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "64": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "96": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "128": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "256": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "512": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "1024": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "1536": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "2048": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "3072": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "4096": {
+        "BLOCK_SIZE_M": 256,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    }
+}
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=2048,device_name=AMD_Instinct_MI300X.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=2048,device_name=AMD_Instinct_MI300X.json
new file mode 100644
index 000000000000..811c77ab4109
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=2048,device_name=AMD_Instinct_MI300X.json
@@ -0,0 +1,200 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "16": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "24": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "32": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "48": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "64": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "96": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "128": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "256": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "512": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 32,
+        "kpack": 2
+    },
+    "1024": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "1536": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "2048": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "3072": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "4096": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    }
+}
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=3584,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=3584,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json
new file mode 100644
index 000000000000..379ca107a946
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=3584,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json
@@ -0,0 +1,164 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "16": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "24": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "32": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "48": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "64": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "96": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "128": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "256": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "512": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "1024": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "1536": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "2048": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "3072": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "4096": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    }
+}
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=3584,device_name=AMD_Instinct_MI300X.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=3584,device_name=AMD_Instinct_MI300X.json
index 3682cc548f35..ed5b655d8993 100644
--- a/vllm/model_executor/layers/fused_moe/configs/E=8,N=3584,device_name=AMD_Instinct_MI300X.json
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=3584,device_name=AMD_Instinct_MI300X.json
@@ -1,21 +1,21 @@
 {
     "1": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 16,
-        "BLOCK_SIZE_K": 128,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
         "GROUP_SIZE_M": 1,
-        "num_warps": 2,
+        "num_warps": 4,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "2": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 16,
-        "BLOCK_SIZE_K": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
         "GROUP_SIZE_M": 1,
-        "num_warps": 2,
+        "num_warps": 4,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
@@ -23,10 +23,10 @@
     },
     "4": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 32,
-        "BLOCK_SIZE_K": 256,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
         "GROUP_SIZE_M": 1,
-        "num_warps": 2,
+        "num_warps": 4,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
@@ -34,7 +34,7 @@
     },
     "8": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_N": 16,
         "BLOCK_SIZE_K": 256,
         "GROUP_SIZE_M": 1,
         "num_warps": 2,
@@ -52,32 +52,32 @@
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 2
+        "kpack": 1
     },
     "24": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 64,
-        "BLOCK_SIZE_K": 64,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 256,
         "GROUP_SIZE_M": 1,
-        "num_warps": 4,
+        "num_warps": 2,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "32": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_N": 32,
         "BLOCK_SIZE_K": 256,
         "GROUP_SIZE_M": 4,
         "num_warps": 2,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 2
+        "kpack": 1
     },
     "48": {
-        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_M": 32,
         "BLOCK_SIZE_N": 32,
         "BLOCK_SIZE_K": 256,
         "GROUP_SIZE_M": 1,
@@ -85,7 +85,7 @@
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 2
+        "kpack": 1
     },
     "64": {
         "BLOCK_SIZE_M": 32,
@@ -101,40 +101,40 @@
     "96": {
         "BLOCK_SIZE_M": 32,
         "BLOCK_SIZE_N": 32,
-        "BLOCK_SIZE_K": 128,
+        "BLOCK_SIZE_K": 256,
         "GROUP_SIZE_M": 4,
-        "num_warps": 4,
+        "num_warps": 2,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "128": {
         "BLOCK_SIZE_M": 64,
         "BLOCK_SIZE_N": 64,
-        "BLOCK_SIZE_K": 128,
-        "GROUP_SIZE_M": 4,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
         "num_warps": 8,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "256": {
-        "BLOCK_SIZE_M": 128,
-        "BLOCK_SIZE_N": 128,
-        "BLOCK_SIZE_K": 64,
-        "GROUP_SIZE_M": 4,
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
         "num_warps": 8,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "512": {
         "BLOCK_SIZE_M": 64,
         "BLOCK_SIZE_N": 128,
-        "BLOCK_SIZE_K": 64,
+        "BLOCK_SIZE_K": 128,
         "GROUP_SIZE_M": 1,
         "num_warps": 8,
         "num_stages": 2,
@@ -151,7 +151,7 @@
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "1536": {
         "BLOCK_SIZE_M": 128,
@@ -173,7 +173,7 @@
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "3072": {
         "BLOCK_SIZE_M": 128,
@@ -195,6 +195,6 @@
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     }
 }
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=4096,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=4096,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json
new file mode 100644
index 000000000000..48bb5f2ccb8e
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=4096,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json
@@ -0,0 +1,164 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "16": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "24": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "32": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "48": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "64": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "96": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "128": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "256": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "512": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "1024": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "1536": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "2048": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "3072": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "4096": {
+        "BLOCK_SIZE_M": 256,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    }
+}
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=4096,device_name=AMD_Instinct_MI300X.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=4096,device_name=AMD_Instinct_MI300X.json
new file mode 100644
index 000000000000..a64d06c6d172
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=4096,device_name=AMD_Instinct_MI300X.json
@@ -0,0 +1,200 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "16": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "24": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "32": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "48": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "64": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "96": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "128": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "256": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 32,
+        "kpack": 2
+    },
+    "512": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "1024": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "1536": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "2048": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "3072": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "4096": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    }
+}
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=7168,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=7168,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json
new file mode 100644
index 000000000000..bd2c6fbc1b94
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=7168,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json
@@ -0,0 +1,164 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "16": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "24": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "32": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "48": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "64": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "96": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "128": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "256": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "512": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "1024": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "1536": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "2048": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "3072": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "4096": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    }
+}
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=7168,device_name=AMD_Instinct_MI300X.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=7168,device_name=AMD_Instinct_MI300X.json
index 21742854c613..822f04e33e87 100644
--- a/vllm/model_executor/layers/fused_moe/configs/E=8,N=7168,device_name=AMD_Instinct_MI300X.json
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=7168,device_name=AMD_Instinct_MI300X.json
@@ -1,7 +1,7 @@
 {
     "1": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_N": 32,
         "BLOCK_SIZE_K": 256,
         "GROUP_SIZE_M": 1,
         "num_warps": 2,
@@ -12,54 +12,54 @@
     },
     "2": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 64,
-        "BLOCK_SIZE_K": 32,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
         "GROUP_SIZE_M": 1,
-        "num_warps": 4,
+        "num_warps": 2,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "4": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 32,
-        "BLOCK_SIZE_K": 128,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
         "GROUP_SIZE_M": 1,
-        "num_warps": 4,
+        "num_warps": 2,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "8": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_N": 16,
         "BLOCK_SIZE_K": 256,
         "GROUP_SIZE_M": 1,
-        "num_warps": 2,
+        "num_warps": 1,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "16": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 16,
-        "BLOCK_SIZE_K": 256,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
         "GROUP_SIZE_M": 1,
-        "num_warps": 4,
+        "num_warps": 2,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 2
+        "kpack": 1
     },
     "24": {
-        "BLOCK_SIZE_M": 32,
-        "BLOCK_SIZE_N": 32,
-        "BLOCK_SIZE_K": 128,
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
         "GROUP_SIZE_M": 1,
-        "num_warps": 8,
+        "num_warps": 1,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
@@ -68,7 +68,7 @@
     "32": {
         "BLOCK_SIZE_M": 16,
         "BLOCK_SIZE_N": 32,
-        "BLOCK_SIZE_K": 128,
+        "BLOCK_SIZE_K": 256,
         "GROUP_SIZE_M": 4,
         "num_warps": 2,
         "num_stages": 2,
@@ -78,32 +78,32 @@
     },
     "48": {
         "BLOCK_SIZE_M": 16,
-        "BLOCK_SIZE_N": 32,
-        "BLOCK_SIZE_K": 128,
-        "GROUP_SIZE_M": 4,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
         "num_warps": 2,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "64": {
         "BLOCK_SIZE_M": 32,
-        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_N": 64,
         "BLOCK_SIZE_K": 128,
         "GROUP_SIZE_M": 4,
         "num_warps": 4,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 2
+        "kpack": 1
     },
     "96": {
         "BLOCK_SIZE_M": 32,
-        "BLOCK_SIZE_N": 32,
-        "BLOCK_SIZE_K": 128,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
         "GROUP_SIZE_M": 4,
-        "num_warps": 4,
+        "num_warps": 8,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
@@ -112,18 +112,18 @@
     "128": {
         "BLOCK_SIZE_M": 64,
         "BLOCK_SIZE_N": 64,
-        "BLOCK_SIZE_K": 64,
+        "BLOCK_SIZE_K": 128,
         "GROUP_SIZE_M": 4,
         "num_warps": 8,
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "256": {
         "BLOCK_SIZE_M": 128,
         "BLOCK_SIZE_N": 128,
-        "BLOCK_SIZE_K": 64,
+        "BLOCK_SIZE_K": 128,
         "GROUP_SIZE_M": 4,
         "num_warps": 8,
         "num_stages": 2,
@@ -140,7 +140,7 @@
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "1024": {
         "BLOCK_SIZE_M": 128,
@@ -151,7 +151,7 @@
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "1536": {
         "BLOCK_SIZE_M": 128,
@@ -173,7 +173,7 @@
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     },
     "3072": {
         "BLOCK_SIZE_M": 128,
@@ -187,7 +187,7 @@
         "kpack": 2
     },
     "4096": {
-        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_M": 256,
         "BLOCK_SIZE_N": 128,
         "BLOCK_SIZE_K": 64,
         "GROUP_SIZE_M": 1,
@@ -195,6 +195,6 @@
         "num_stages": 2,
         "waves_per_eu": 0,
         "matrix_instr_nonkdim": 16,
-        "kpack": 1
+        "kpack": 2
     }
 }
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=8192,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=8192,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json
new file mode 100644
index 000000000000..cd4fb8f11b93
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=8192,device_name=AMD_Instinct_MI300X,dtype=fp8_w8a8.json
@@ -0,0 +1,164 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "16": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 1,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "24": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "32": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "48": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "64": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 1,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "96": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "128": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "256": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "512": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "1024": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "1536": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "2048": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "3072": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    },
+    "4096": {
+        "BLOCK_SIZE_M": 256,
+        "BLOCK_SIZE_N": 256,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0
+    }
+}
diff --git a/vllm/model_executor/layers/fused_moe/configs/E=8,N=8192,device_name=AMD_Instinct_MI300X.json b/vllm/model_executor/layers/fused_moe/configs/E=8,N=8192,device_name=AMD_Instinct_MI300X.json
new file mode 100644
index 000000000000..cf66868e9d57
--- /dev/null
+++ b/vllm/model_executor/layers/fused_moe/configs/E=8,N=8192,device_name=AMD_Instinct_MI300X.json
@@ -0,0 +1,200 @@
+{
+    "1": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 1,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "2": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "4": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "8": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 16,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 1,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 1
+    },
+    "16": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "24": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "32": {
+        "BLOCK_SIZE_M": 16,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 128,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 2,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "48": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "64": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "96": {
+        "BLOCK_SIZE_M": 32,
+        "BLOCK_SIZE_N": 32,
+        "BLOCK_SIZE_K": 256,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "128": {
+        "BLOCK_SIZE_M": 64,
+        "BLOCK_SIZE_N": 64,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 4,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "256": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 4,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "512": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "1024": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "1536": {
+        "BLOCK_SIZE_M": 128,
+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
+        "GROUP_SIZE_M": 1,
+        "num_warps": 8,
+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    },
+    "2048": {
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+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
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+        "num_stages": 2,
+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
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+    },
+    "3072": {
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+        "kpack": 2
+    },
+    "4096": {
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+        "BLOCK_SIZE_N": 128,
+        "BLOCK_SIZE_K": 64,
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+        "waves_per_eu": 0,
+        "matrix_instr_nonkdim": 16,
+        "kpack": 2
+    }
+}