Make apply_type_nothrow robust against TypeVars in upper bounds
#49863
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For types like
Foo{S, T<:S},apply_type_nothrowcould in some situations check whether the argument is a subtype of the upper bound ofT, i.e.S, but subtyping agaist a plainTypeVarwould fail. Instead returnfalsein this case.Fixes #49785.