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Scripts to reproduce the results of Buchfink et al., "Sensitive clustering of protein sequences at tree-of-life scale using DIAMOND DeepClust".

Data files

Data files that are required (see Data availability):

  • arch80_all.tsv: File mapping NCBI accessions to Pfam domain architectures.
  • nr_accessions.tsv.zst: List of all accessions in NR database that was used for the main benchmark.
  • reps_1M_ge5.tsv.zst: List of accessions of randomly sampled representatives of the big ~19bn clustering run of clusters of size >= 5.
  • clan2acc.tsv: File mapping Pfam accessions to clans.
  • reps_10k.ge2.faa: Sequences of 10k randomly sampled representatives of the big ~19bn clustering run of clusters of size >= 2.
  • reps_10k.ge3.faa: Sequences of 10k randomly sampled representatives of the big ~19bn clustering run of clusters of size >= 3.
  • clust.dedup2.tsv.zst: TSV file mapping cluster member sequences to representatives for the big ~19bn clustering run.
  • centroids.dedup.faa: FASTA file of representatives for the big ~19bn clustering run.

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